Research ArticleOriginal Article
Open Access
Synergistic efficacies of thymoquinone and standard antibiotics against multi-drug resistant isolates
Ayed A. Dera, Irfan Ahmad, Prasanna Rajagopalan, Mesfer Al Shahrani, Ahmed Saif, Mohammad Y. Alshahrani, Yasser Alraey, Ahmad M. Alamri, Sultan Alasmari, Mohammed Makkawi, Ali G. Alkhathami, Gaffar Zaman, Abdulrahim Hakami, Razan Alhefzi and Mohammad A. Alfhili
Saudi Medical Journal February 2021, 42 (2) 196-204; DOI: https://doi.org/10.15537/smj.2021.2.25706
Ayed A. Dera
From the Department of Clinical Laboratory Sciences, Central Research Laboratory (Dera, Ahmad, Rajagopalan, Al Shahrani, Alshahrani, Alraey, Alamri, Alasmari, Makkawi, Alkhathami, Zaman, Hakami, Alhefzi), College of Applied Medical Sciences, King Khalid University, and From the Department of Clinical Laboratory Sciences, Central Research Laboratory (AlAmri), College of Applied Medical Sciences, and Cancer Research Unit, King Khalid University, Abha; from the Department of Clinical Laboratory Sciences (Saif), College of Applied Medical Sciences, Najran University, Najran; and the Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences (Alfhili), College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.
PhDIrfan Ahmad
From the Department of Clinical Laboratory Sciences, Central Research Laboratory (Dera, Ahmad, Rajagopalan, Al Shahrani, Alshahrani, Alraey, Alamri, Alasmari, Makkawi, Alkhathami, Zaman, Hakami, Alhefzi), College of Applied Medical Sciences, King Khalid University, and From the Department of Clinical Laboratory Sciences, Central Research Laboratory (AlAmri), College of Applied Medical Sciences, and Cancer Research Unit, King Khalid University, Abha; from the Department of Clinical Laboratory Sciences (Saif), College of Applied Medical Sciences, Najran University, Najran; and the Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences (Alfhili), College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.
PhDPrasanna Rajagopalan
From the Department of Clinical Laboratory Sciences, Central Research Laboratory (Dera, Ahmad, Rajagopalan, Al Shahrani, Alshahrani, Alraey, Alamri, Alasmari, Makkawi, Alkhathami, Zaman, Hakami, Alhefzi), College of Applied Medical Sciences, King Khalid University, and From the Department of Clinical Laboratory Sciences, Central Research Laboratory (AlAmri), College of Applied Medical Sciences, and Cancer Research Unit, King Khalid University, Abha; from the Department of Clinical Laboratory Sciences (Saif), College of Applied Medical Sciences, Najran University, Najran; and the Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences (Alfhili), College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.
PhDMesfer Al Shahrani
From the Department of Clinical Laboratory Sciences, Central Research Laboratory (Dera, Ahmad, Rajagopalan, Al Shahrani, Alshahrani, Alraey, Alamri, Alasmari, Makkawi, Alkhathami, Zaman, Hakami, Alhefzi), College of Applied Medical Sciences, King Khalid University, and From the Department of Clinical Laboratory Sciences, Central Research Laboratory (AlAmri), College of Applied Medical Sciences, and Cancer Research Unit, King Khalid University, Abha; from the Department of Clinical Laboratory Sciences (Saif), College of Applied Medical Sciences, Najran University, Najran; and the Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences (Alfhili), College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.
PhDAhmed Saif
From the Department of Clinical Laboratory Sciences, Central Research Laboratory (Dera, Ahmad, Rajagopalan, Al Shahrani, Alshahrani, Alraey, Alamri, Alasmari, Makkawi, Alkhathami, Zaman, Hakami, Alhefzi), College of Applied Medical Sciences, King Khalid University, and From the Department of Clinical Laboratory Sciences, Central Research Laboratory (AlAmri), College of Applied Medical Sciences, and Cancer Research Unit, King Khalid University, Abha; from the Department of Clinical Laboratory Sciences (Saif), College of Applied Medical Sciences, Najran University, Najran; and the Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences (Alfhili), College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.
PhDMohammad Y. Alshahrani
From the Department of Clinical Laboratory Sciences, Central Research Laboratory (Dera, Ahmad, Rajagopalan, Al Shahrani, Alshahrani, Alraey, Alamri, Alasmari, Makkawi, Alkhathami, Zaman, Hakami, Alhefzi), College of Applied Medical Sciences, King Khalid University, and From the Department of Clinical Laboratory Sciences, Central Research Laboratory (AlAmri), College of Applied Medical Sciences, and Cancer Research Unit, King Khalid University, Abha; from the Department of Clinical Laboratory Sciences (Saif), College of Applied Medical Sciences, Najran University, Najran; and the Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences (Alfhili), College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.
PhDYasser Alraey
From the Department of Clinical Laboratory Sciences, Central Research Laboratory (Dera, Ahmad, Rajagopalan, Al Shahrani, Alshahrani, Alraey, Alamri, Alasmari, Makkawi, Alkhathami, Zaman, Hakami, Alhefzi), College of Applied Medical Sciences, King Khalid University, and From the Department of Clinical Laboratory Sciences, Central Research Laboratory (AlAmri), College of Applied Medical Sciences, and Cancer Research Unit, King Khalid University, Abha; from the Department of Clinical Laboratory Sciences (Saif), College of Applied Medical Sciences, Najran University, Najran; and the Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences (Alfhili), College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.
PhDAhmad M. Alamri
From the Department of Clinical Laboratory Sciences, Central Research Laboratory (Dera, Ahmad, Rajagopalan, Al Shahrani, Alshahrani, Alraey, Alamri, Alasmari, Makkawi, Alkhathami, Zaman, Hakami, Alhefzi), College of Applied Medical Sciences, King Khalid University, and From the Department of Clinical Laboratory Sciences, Central Research Laboratory (AlAmri), College of Applied Medical Sciences, and Cancer Research Unit, King Khalid University, Abha; from the Department of Clinical Laboratory Sciences (Saif), College of Applied Medical Sciences, Najran University, Najran; and the Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences (Alfhili), College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.
PhDSultan Alasmari
From the Department of Clinical Laboratory Sciences, Central Research Laboratory (Dera, Ahmad, Rajagopalan, Al Shahrani, Alshahrani, Alraey, Alamri, Alasmari, Makkawi, Alkhathami, Zaman, Hakami, Alhefzi), College of Applied Medical Sciences, King Khalid University, and From the Department of Clinical Laboratory Sciences, Central Research Laboratory (AlAmri), College of Applied Medical Sciences, and Cancer Research Unit, King Khalid University, Abha; from the Department of Clinical Laboratory Sciences (Saif), College of Applied Medical Sciences, Najran University, Najran; and the Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences (Alfhili), College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.
PhDMohammed Makkawi
From the Department of Clinical Laboratory Sciences, Central Research Laboratory (Dera, Ahmad, Rajagopalan, Al Shahrani, Alshahrani, Alraey, Alamri, Alasmari, Makkawi, Alkhathami, Zaman, Hakami, Alhefzi), College of Applied Medical Sciences, King Khalid University, and From the Department of Clinical Laboratory Sciences, Central Research Laboratory (AlAmri), College of Applied Medical Sciences, and Cancer Research Unit, King Khalid University, Abha; from the Department of Clinical Laboratory Sciences (Saif), College of Applied Medical Sciences, Najran University, Najran; and the Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences (Alfhili), College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.
PhDAli G. Alkhathami
From the Department of Clinical Laboratory Sciences, Central Research Laboratory (Dera, Ahmad, Rajagopalan, Al Shahrani, Alshahrani, Alraey, Alamri, Alasmari, Makkawi, Alkhathami, Zaman, Hakami, Alhefzi), College of Applied Medical Sciences, King Khalid University, and From the Department of Clinical Laboratory Sciences, Central Research Laboratory (AlAmri), College of Applied Medical Sciences, and Cancer Research Unit, King Khalid University, Abha; from the Department of Clinical Laboratory Sciences (Saif), College of Applied Medical Sciences, Najran University, Najran; and the Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences (Alfhili), College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.
PhDGaffar Zaman
From the Department of Clinical Laboratory Sciences, Central Research Laboratory (Dera, Ahmad, Rajagopalan, Al Shahrani, Alshahrani, Alraey, Alamri, Alasmari, Makkawi, Alkhathami, Zaman, Hakami, Alhefzi), College of Applied Medical Sciences, King Khalid University, and From the Department of Clinical Laboratory Sciences, Central Research Laboratory (AlAmri), College of Applied Medical Sciences, and Cancer Research Unit, King Khalid University, Abha; from the Department of Clinical Laboratory Sciences (Saif), College of Applied Medical Sciences, Najran University, Najran; and the Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences (Alfhili), College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.
MDAbdulrahim Hakami
From the Department of Clinical Laboratory Sciences, Central Research Laboratory (Dera, Ahmad, Rajagopalan, Al Shahrani, Alshahrani, Alraey, Alamri, Alasmari, Makkawi, Alkhathami, Zaman, Hakami, Alhefzi), College of Applied Medical Sciences, King Khalid University, and From the Department of Clinical Laboratory Sciences, Central Research Laboratory (AlAmri), College of Applied Medical Sciences, and Cancer Research Unit, King Khalid University, Abha; from the Department of Clinical Laboratory Sciences (Saif), College of Applied Medical Sciences, Najran University, Najran; and the Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences (Alfhili), College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.
PhDRazan Alhefzi
From the Department of Clinical Laboratory Sciences, Central Research Laboratory (Dera, Ahmad, Rajagopalan, Al Shahrani, Alshahrani, Alraey, Alamri, Alasmari, Makkawi, Alkhathami, Zaman, Hakami, Alhefzi), College of Applied Medical Sciences, King Khalid University, and From the Department of Clinical Laboratory Sciences, Central Research Laboratory (AlAmri), College of Applied Medical Sciences, and Cancer Research Unit, King Khalid University, Abha; from the Department of Clinical Laboratory Sciences (Saif), College of Applied Medical Sciences, Najran University, Najran; and the Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences (Alfhili), College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.
MScMohammad A. Alfhili
From the Department of Clinical Laboratory Sciences, Central Research Laboratory (Dera, Ahmad, Rajagopalan, Al Shahrani, Alshahrani, Alraey, Alamri, Alasmari, Makkawi, Alkhathami, Zaman, Hakami, Alhefzi), College of Applied Medical Sciences, King Khalid University, and From the Department of Clinical Laboratory Sciences, Central Research Laboratory (AlAmri), College of Applied Medical Sciences, and Cancer Research Unit, King Khalid University, Abha; from the Department of Clinical Laboratory Sciences (Saif), College of Applied Medical Sciences, Najran University, Najran; and the Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences (Alfhili), College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.
PhDArticle Information
vol. 42 no. 2 196-204
PubMed
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History
- Received November 14, 2020
- Accepted January 14, 2021
- Published online February 9, 2021.
Copyright & Usage
Copyright: © Saudi Medical Journal This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Author Information
- Ayed A. Dera, PhD,
- Irfan Ahmad, PhD,
- Prasanna Rajagopalan, PhD,
- Mesfer Al Shahrani, PhD,
- Ahmed Saif, PhD,
- Mohammad Y. Alshahrani, PhD,
- Yasser Alraey, PhD,
- Ahmad M. Alamri, PhD,
- Sultan Alasmari, PhD,
- Mohammed Makkawi, PhD,
- Ali G. Alkhathami, PhD,
- Gaffar Zaman, MD,
- Abdulrahim Hakami, PhD,
- Razan Alhefzi, MSc and
- Mohammad A. Alfhili, PhD
- From the Department of Clinical Laboratory Sciences, Central Research Laboratory (Dera, Ahmad, Rajagopalan, Al Shahrani, Alshahrani, Alraey, Alamri, Alasmari, Makkawi, Alkhathami, Zaman, Hakami, Alhefzi), College of Applied Medical Sciences, King Khalid University, and From the Department of Clinical Laboratory Sciences, Central Research Laboratory (AlAmri), College of Applied Medical Sciences, and Cancer Research Unit, King Khalid University, Abha; from the Department of Clinical Laboratory Sciences (Saif), College of Applied Medical Sciences, Najran University, Najran; and the Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences (Alfhili), College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.
- Address correspondence and reprint request to: Dr. Ayed A. Dera, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia. E-mail: ayedd{at}kku.edu.sa ORCID ID: https://orcid.org/0000-0002-6248-8983
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In this issue
Synergistic efficacies of thymoquinone and standard antibiotics against multi-drug resistant isolates
Ayed A. Dera, Irfan Ahmad, Prasanna Rajagopalan, Mesfer Al Shahrani, Ahmed Saif, Mohammad Y. Alshahrani, Yasser Alraey, Ahmad M. Alamri, Sultan Alasmari, Mohammed Makkawi, Ali G. Alkhathami, Gaffar Zaman, Abdulrahim Hakami, Razan Alhefzi, Mohammad A. Alfhili
Saudi Medical Journal Feb 2021, 42 (2) 196-204; DOI: 10.15537/smj.2021.2.25706
Synergistic efficacies of thymoquinone and standard antibiotics against multi-drug resistant isolates
Ayed A. Dera, Irfan Ahmad, Prasanna Rajagopalan, Mesfer Al Shahrani, Ahmed Saif, Mohammad Y. Alshahrani, Yasser Alraey, Ahmad M. Alamri, Sultan Alasmari, Mohammed Makkawi, Ali G. Alkhathami, Gaffar Zaman, Abdulrahim Hakami, Razan Alhefzi, Mohammad A. Alfhili
Saudi Medical Journal Feb 2021, 42 (2) 196-204; DOI: 10.15537/smj.2021.2.25706
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