Roles of nucleolin: Focus on cancer and anti-cancer therapy

Zhuo Chen; XinHua Xu

doi:10.15537/smj.2016.12.15972

Review ArticleReview Article

Open Access

Roles of nucleolin

Focus on cancer and anti-cancer therapy

Zhuo Chen and XinHua Xu

Saudi Medical Journal December 2016, 37 (12) 1312-1318; DOI: https://doi.org/10.15537/smj.2016.12.15972

Zhuo Chen

From the Department of Oncology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang, China

MMed

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

XinHua Xu

From the Department of Oncology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang, China

MMed

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: [email protected]

Article
Figures & Data
eLetters
Info & Metrics
References
PDF

Article Information

vol. 37 no. 12 1312-1318

DOI

https://doi.org/10.15537/smj.2016.12.15972

PubMed

27874146

Published By

Saudi Medical Journal

Online ISSN

1658-3175

History

Published online December 1, 2016.

Copyright: © Saudi Medical Journal This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Information

Zhuo Chen, MMed and
XinHua Xu, MMed ⇑

From the Department of Oncology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang, China

Address correspondence and reprint request to: Prof. XinHua Xu, Department of Oncology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang, China. E-mail: xuxinhua{at}medmail.com.cn

View Full Text

Cited By...

66 Citations
64 Citations
Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

Therapeutic applications of AS1411 aptamer, an update review

Rezvan Yazdian-Robati, Payam Bayat, Fatemeh Oroojalian, Mehryar Zargari, Mohammad Ramezani, Seyed Mohammad Taghdisi, Khalil Abnous

International Journal of Biological Macromolecules 2020 155
The nucleolus: a central response hub for the stressors that drive cancer progression

Shannon E. Weeks, Brandon J. Metge, Rajeev S. Samant

Cellular and Molecular Life Sciences 2019 76 22
pH-controlled nucleolin targeted release of dual drug from chitosan-gold based aptamer functionalized nano drug delivery system for improved glioblastoma treatment

Anbazhagan Sathiyaseelan, Kandasamy Saravanakumar, Arokia Vijaya Anand Mariadoss, Myeong-Hyeon Wang

Carbohydrate Polymers 2021 262
Biosensors Made of Synthetic Functional Nucleic Acids Toward Better Human Health

Erin M. McConnell, Ioana Cozma, Devon Morrison, Yingfu Li

Analytical Chemistry 2020 92 1
An exploration of aptamer internalization mechanisms and their applications in drug delivery

Lin-Yan Wan, Wen-Fang Yuan, Wen-Bing Ai, Yao-Wei Ai, Jiao-Jiao Wang, Liang-Yin Chu, Yan-Qiong Zhang, Jiang-Feng Wu

Expert Opinion on Drug Delivery 2019 16 3
<p>Targeted Treatment of Colon Cancer with Aptamer-Guided Albumin Nanoparticles Loaded with Docetaxel</p>

Zhen Yu, Xundou Li, Jinhong Duan, Xian-Da Yang

International Journal of Nanomedicine 2020 Volume 15
Functionalized liposomes for targeted breast cancer drug delivery

Janske Nel, Kamil Elkhoury, Émilie Velot, Arnaud Bianchi, Samir Acherar, Grégory Francius, Ali Tamayol, Stéphanie Grandemange, Elmira Arab-Tehrany

Bioactive Materials 2023 24
Cancer hallmarks and malignancy features: Gateway for improved targeted drug delivery

Tiatou Souho, Lallepak Lamboni, Lin Xiao, Guang Yang

Biotechnology Advances 2018 36 7
Fabrication of aptamer modified TiO2 nanofibers for specific capture of circulating tumor cells

Hui Liu, Na Sun, Pi Ding, Changchong Chen, Zeen Wu, Weipei Zhu, Lifen Liu, Zhili Wang, Renjun Pei

Colloids and Surfaces B: Biointerfaces 2020 191
Identification and validation nucleolin as a target of curcumol in nasopharyngeal carcinoma cells

Juan Wang, Jiacai Wu, Xumei Li, Haowei Liu, Jianli Qin, Zhun Bai, Bixia Chi, Xu Chen

Journal of Proteomics 2018 182
Molecular determinants as therapeutic targets in cancer chemotherapy: An update

Tanweer Haider, Rahul Tiwari, Suresh Prasad Vyas, Vandana Soni

Pharmacology & Therapeutics 2019 200
Aptamer‐conjugated mesoporous polydopamine for docetaxel targeted delivery and synergistic photothermal therapy of prostate cancer

Liang Dai, Dapeng Wei, Jidong Zhang, Tianyu Shen, Yuming Zhao, Junqiang Liang, Wangteng Ma, Limin Zhang, Qingli Liu, Yue Zheng

Cell Proliferation 2021 54 11
Nucleic-Acid-Based Targeted Degradation in Drug Discovery

Wei Wang, Shipeng He, Guoqiang Dong, Chunquan Sheng

Journal of Medicinal Chemistry 2022 65 15
Breast Cancer Aptamers: Current Sensing Targets, Available Aptamers, and Their Evaluation for Clinical Use in Diagnostics

Kathleen Varty, Connor O’Brien, Anna Ignaszak

Cancers 2021 13 16
Cell surface nucleolin as active bait for nanomedicine in cancer therapy: a promising option

Benedetta Ferrara, Sabrina Belbekhouche, Damien Habert, Claire Houppe, Benoit Vallée, Sandrine Bourgoin-Voillard, José L Cohen, Ilaria Cascone, José Courty

Nanotechnology 2021 32 32
Advances in aptamer-based drug delivery vehicles for cancer therapy

Kousar Ghasemii, Mahdieh Darroudi, Ilnaz Rahimmanesh, Matineh Ghomi, Mahnaz Hassanpour, Esmaeel Sharifi, Satar Yousefiasl, Sepideh Ahmadi, Ali Zarrabi, Assunta Borzacchiello, Mohammad Rabiee, Ana Cláudia Paiva-Santos, Navid Rabiee

Biomaterials Advances 2022 140
Aptamer‐functionalized quantum dots as theranostic nanotools against cancer and bacterial infections: A comprehensive overview of recent trends

Fatemeh Davodabadi, Shekoufeh Mirinejad, Sonia Fathi‐Karkan, Mahdi Majidpour, Narges Ajalli, Roghayeh Sheervalilou, Saman Sargazi, Dominika Rozmus, Abbas Rahdar, Ana M. Diez‐Pascual

Biotechnology Progress 2023 39 5
Functional Nucleic‐Acid‐Decorated Spherical Nanoparticles: Preparation Strategies and Current Applications in Cancer Therapy

Min Zhu, Shan Wang

Small Science 2021 1 3
BMH-21 inhibits viability and induces apoptosis by p53-dependent nucleolar stress responses in SKOV3 ovarian cancer cells

Xinxu Fu, Lu Xu, Ling Qi, Hongyan Tian, Dan Yi, Yang Yu, Shibing Liu, Songyan Li, Ye Xu, Chunyan Wang

Oncology Reports 2017 38 2
Cancer-Specific Delivery of Proteolysis-Targeting Chimeras (PROTACs) and Their Application to Cancer Immunotherapy

Yujeong Moon, Seong Ik Jeon, Man Kyu Shim, Kwangmeyung Kim

Pharmaceutics 2023 15 2
Nucleolin facilitates nuclear retention of an ultraconserved region containing TRA2β4 and accelerates colon cancer cell growth

Yuzuru Satake, Yuki Kuwano, Tatsuya Nishikawa, Kinuyo Fujita, Saki Saijo, Miki Itai, Hiroki Tanaka, Kensei Nishida, Kazuhito Rokutan

Oncotarget 2018 9 42
Nucleolin Mediates LPS-induced Expression of Inflammatory Mediators and Activation of Signaling Pathways

Li Fang, Kang-kai Wang, Qing Huang, Feng Cheng, Fang Huang, Wei-wei Liu

Current Medical Science 2020 40 4
Aptamers as Theragnostic Tools in Prostate Cancer

Carlos David Cruz-Hernández, Griselda Rodríguez-Martínez, Sergio A. Cortés-Ramírez, Miguel Morales-Pacheco, Marian Cruz-Burgos, Alberto Losada-García, Juan Pablo Reyes-Grajeda, Imelda González-Ramírez, Vanessa González-Covarrubias, Ignacio Camacho-Arroyo, Marco Cerbón, Mauricio Rodríguez-Dorantes

Biomolecules 2022 12 8
Multifunctional Theranostic Nanoparticles for Enhanced Tumor Targeted Imaging and Synergistic FUS/Chemotherapy on Murine 4T1 Breast Cancer Cell

Zhengyue Kang, Min Yang, Xiaoling Feng, Hongjian Liao, Zhifei Zhang, Yonghong Du

International Journal of Nanomedicine 2022 Volume 17
Nucleolin Promotes Cisplatin Resistance in Cervical Cancer by the YB1-MDR1 Pathway

Jing Ke, Chunming Gu, Heyan Zhang, Yang Liu, Wenhao Zhang, Huiling Rao, Shan Li, Fuyun Wu, Prasanna Kumar Santhekadur

Journal of Oncology 2021 2021
Nucleolin promotes Ang II‐induced phenotypic transformation of vascular smooth muscle cells by regulating EGF and PDGF‐BB

Li Fang, Kang‐Kai Wang, Peng‐Fei Zhang, Tao Li, Zhi‐Lin Xiao, Mei Yang, Zai‐Xin Yu

Journal of Cellular and Molecular Medicine 2020 24 2
Overexpression of ARHGAP30 suppresses growth of cervical cancer cells by downregulating ribosome biogenesis

Aijia Wu, Lan Lin, Xiao Li, Qinyang Xu, Wei Xu, Xiaolu Zhu, Yincheng Teng, Xiao‐Mei Yang, Zhihong Ai

Cancer Science 2021 112 11
RNA Helicase DDX24 Stabilizes LAMB1 to Promote Hepatocellular Carcinoma Progression

Tianze Liu, Hairun Gan, Simeng He, Jia Deng, Xinyan Hu, Luting Li, Li Cai, Jianzhong He, Haoyu Long, Jianxun Cai, Hanjie Li, Qianqian Zhang, Lijie Wang, Fangbin Chen, Yuming Chen, Haopei Zhang, Jian Li, Lukun Yang, Ye Liu, Jian-Hua Yang, Dong-Ming Kuang, Pengfei Pang, Huanhuan He, Hong Shan

Cancer Research 2022 82 17
Curcumin arrests G-quadruplex in the nuclear hyper-sensitive III1 element of c-MYC oncogene leading to apoptosis in metastatic breast cancer cells

Ananya Roy, Oishika Chatterjee, Nilanjan Banerjee, Tanaya Roychowdhury, Gopa Dhar, Gopeswar Mukherjee, Subhrangsu Chatterjee

Journal of Biomolecular Structure and Dynamics 2022 40 20
Aptamer nucleotide analog drug conjugates in the targeting therapy of cancers

Yongshu Li, Jing Zhao, Zhichao Xue, Chiman Tsang, Xiaoting Qiao, Lianhua Dong, Huijie Li, Yi Yang, Bin Yu, Yunhua Gao

Frontiers in Cell and Developmental Biology 2022 10
Enhanced theranostic efficacy of epirubicin-loaded SPION@MSN through co-delivery of an anti-miR-21-expressing plasmid and ZIF-8 hybridization to target colon adenocarcinoma

Amir Abrishami, Ahmad Reza Bahrami, Amir Sh. Saljooghi, Maryam M. Matin

Nanoscale 2024 16 12
“Domino” cascade reactor based on DNA hydrogel for synergistic treatment of malignant tumor

Xiaofan Liu, Minghui Ma, Shuo Tian, Weicai Wang, Xuemei Li

European Journal of Medicinal Chemistry 2023 256
Aptamer-Functionalized Natural Protein-Based Polymers as Innovative Biomaterials

Alessandra Girotti, Sara Escalera-Anzola, Irene Alonso-Sampedro, Juan González-Valdivieso, Francisco Javier Arias

Pharmaceutics 2020 12 11
Aptamers as Potential Therapeutic Tools for Ovarian Cancer: Advancements and Challenges

Wojciech Szymanowski, Anna Szymanowska, Anna Bielawska, Gabriel Lopez-Berestein, Cristian Rodriguez-Aguayo, Paola Amero

Cancers 2023 15 21
CRYβB2 enhances tumorigenesis through upregulation of nucleolin in triple negative breast cancer

Yu Yan, Athira Narayan, Soonweng Cho, Zhiqiang Cheng, Jun O. Liu, Heng Zhu, Guannan Wang, Bryan Wharram, Ala Lisok, Mary Brummet, Harumi Saeki, Tao Huang, Kathleen Gabrielson, Edward Gabrielson, Leslie Cope, Yasmine M. Kanaan, Ali Afsari, Tammey Naab, Harris G. Yfantis, Stefan Ambs, Martin G. Pomper, Saraswati Sukumar, Vanessa F. Merino

Oncogene 2021 40 38
NCL Inhibition Exerts Antineoplastic Effects against Prostate Cancer Cells by Modulating Oncogenic MicroRNAs

Tyler Sheetz, Joseph Mills, Anna Tessari, Megan Pawlikowski, Ashley E. Braddom, Tasha Posid, Debra L. Zynger, Cindy James, Valerio Embrione, Kareesma Parbhoo, Claudia Foray, Vincenzo Coppola, Carlo M. Croce, Dario Palmieri

Cancers 2020 12 7
A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene

Gregory R. Moe, Lindsay M. Steirer, Joshua A. Lee, Adarsha Shivakumar, Alejandro D. Bolanos

Journal of Experimental & Clinical Cancer Research 2021 40 1
Future Perspectives of Therapeutic, Diagnostic and Prognostic Aptamers in Eye Pathological Angiogenesis

Emilio Iturriaga-Goyon, Beatriz Buentello-Volante, Fátima Sofía Magaña-Guerrero, Yonathan Garfias

Cells 2021 10 6
Nucleolin‑based targeting strategies in cancer treatment: Focus on cancer immunotherapy (Review)

Suyanee Thongchot, Krittaya Aksonnam, Peti Thuwajit, Pa-Thai Yenchitsomanus, Chanitra Thuwajit

International Journal of Molecular Medicine 2023 52 3
Targeted drug conjugate systems for ovarian cancer chemotherapy

Omotola D. Ogundipe, Oluwabukunmi Olajubutu, Simeon K. Adesina

Biomedicine & Pharmacotherapy 2023 165
Engineering G-quadruplex aptamer to modulate its binding specificity

Long Li, Shujuan Xu, Xueyu Peng, Yuzhuo Ji, He Yan, Cheng Cui, Xiaowei Li, Xiaoshu Pan, Lu Yang, Liping Qiu, Jianhui Jiang, Weihong Tan

National Science Review 2021 8 4
AS1411 aptamer improves therapeutic efficacy of PEGylated nanoliposomes loaded with gefitinib in the mice bearing CT26 colon carcinoma

Hamid Tanzadehpanah, Hanie Mahaki, Hamed Manoochehri, Meysam Soleimani, Rezvan Najafi

Journal of Nanoparticle Research 2022 24 12
AS1411 aptamer tagged PEGylated liposomes as a smart nanocarrier for tumor-specific delivery of Withaferin A for mitigating pulmonary metastasis

Prathapan Abeesh, Phillipe Bouvet, Chandrasekaran Guruvayoorappan

Biomaterials Advances 2023 154
Anticancer effect of locally applicable aptamer‐conjugated gemcitabine‐loaded atelocollagen patch in pancreatic cancer patient–derived xenograft models

Seung Soo Hong, Sena Lee, Sung Hwan Lee, Seonhowa Kim, Doyoung Kim, Hanseul Park, Jongook Lee, Jung Hwan Lee, Chang Moo Kang

Cancer Science 2022 113 5
Challenges and emerging strategies for next generation liposomal based drug delivery: An account of the breast cancer conundrum

Aliesha Moudgil, Rajesh Salve, Virendra Gajbhiye, Bhushan P. Chaudhari

Chemistry and Physics of Lipids 2023 250
Oncogene-targeting nanoprobes for early imaging detection of tumor

Wenyue Li, Peisen Zhang, Chuang Liu, Yuping Xu, Zhihua Gan, Lei Kang, Yi Hou

Journal of Nanobiotechnology 2023 21 1
RNA-Binding Proteins in Bladder Cancer

Yuanhui Gao, Hui Cao, Denggao Huang, Linlin Zheng, Zhenyu Nie, Shufang Zhang

Cancers 2023 15 4
Role of Nucleolin in Endometrial Precancerous Hyperplasia and Carcinogenesis: Ex Vivo and In Silico Study

Vanya D. Barzilova, Josephine Drury, Bryony Rogers, Emily Thomas, Fareen Ahmed, Alice Bradfield, Hannan Al-Lamee, Dharani K. Hapangama

International Journal of Molecular Sciences 2022 23 11
Transcribed Ultraconserved Regions: New regulators in cancer signaling and potential biomarkers

Jaqueline Carvalho de Oliveira

Genetics and Molecular Biology 2023 46 1 suppl 2
Tumor Suppressor Role of Wild-Type P53-Dependent Secretome and Its Proteomic Identification in PDAC

Giovanna Butera, Marcello Manfredi, Alessandra Fiore, Jessica Brandi, Raffaella Pacchiana, Veronica De Giorgis, Elettra Barberis, Virginia Vanella, Marilisa Galasso, Maria Teresa Scupoli, Emilio Marengo, Daniela Cecconi, Massimo Donadelli

Biomolecules 2022 12 2
Blockage of Orai1-Nucleolin interaction meditated calcium influx attenuates breast cancer cells growth

Chunming Gu, Wenhao Zhang, Enze Yang, Congyou Gu, Zhaoyang Zhang, Jing Ke, Xiong Wang, Shengying Wu, Shan Li, Fuyun Wu

Oncogenesis 2022 11 1
Anti-nucleolin Aptamer as a Boom in Rehabilitation of Breast Cancer

S.K. Janani, S.P. Dhanabal, Raman Sureshkumar, Sai Surya Nikitha Upadhyayula

Current Pharmaceutical Design 2022 28 38
Novel INHAT repressor drives glioblastoma growth by promoting ribosomal DNA transcription in glioma stem cells

Weiwei Tao, Hong Lei, Wenlong Luo, Zhi Huang, Peng Ling, Mengyue Guo, Lihao Wan, Kui Zhai, Qian Huang, Qiulian Wu, Shutong Xu, Liang Zeng, Xiuxing Wang, Zhiqiang Dong, Jeremy N Rich, Shideng Bao

Neuro-Oncology 2023 25 8
Nucleolin and Nucleoli in Ependymocytes and Tanycytes of the Third Ventricle of the Rat Brain

D. A. Sufieva, O. V. Kirik, D. E. Korzhevskii

Cell and Tissue Biology 2018 12 2
An ultrasensitive paper-based SERS sensor for detection of nucleolin using silver-nanostars, plastic antibodies and natural antibodies

Akmaral Suleimenova, Manuela F. Frasco, M. Goreti F. Sales

Talanta 2024 279
Changes in Nucleolin Expression during Malignant Transformation Leading to Ovarian High-Grade Serous Carcinoma

Elizabeth A. Paris, Janice M. Bahr, Sanjib Basu, Animesh Barua

Cancers 2023 15 3
Nucleolin promotes Ang�II‑induced phenotypic transformation of vascular smooth muscle cells via interaction with tropoelastin mRNA

Li Fang, Peng‑Fei Zhang, Kang‑Kai Wang, Zhi‑Lin Xiao, Mei Yang, Zai‑Xin Yu

International Journal of Molecular Medicine 2019
Anti-nuclear valosin-containing protein-like autoantibody is associated with calcinosis and higher risk of cancer in systemic sclerosis

Janire Perurena-Prieto, Laura Viñas-Giménez, María Teresa Sanz-Martínez, Albert Selva-O’Callaghan, Eduardo Luis Callejas-Moraga, Roger Colobran, Alfredo Guillén-Del-Castillo, Carmen P Simeón-Aznar

Rheumatology 2024 63 8
Aptamer-guided Selective Delivery of Therapeutics to Breast Cancer Cells Expressing Specific Biomarkers

Swaroop Kumar Pandey, Mradula Parul, Manikandan Santhanam

Current Cancer Therapy Reviews 2024 20 5
Aptamers Engineered Nanocarriers for Cancer Therapy

Fatemeh Salahpour-Anarjan, Faraz Zare, Farnaz Hosseini, Sara Davari Ahranjani, Mahnaz Alipour, Elahe Gozali

2023
Aptamers for Medical Applications

Ge Yang, Yuanyu Huang

2021
Circular RNA from Tyrosylprotein Sulfotransferase 2 Gene Inhibits Cisplatin Sensitivity in Head and Neck Squamous Cell Carcinoma by Sponging miR-770-5p and Interacting with Nucleolin

Tianqing Wang, Chuan Xin, Shiyu Zhang, Xin Tian, Yuting Hu, Ying Wang, Jiongke Wang, Ning Ji, Xin Zeng, Jing Li

Cancers 2023 15 22
Expression and Clinical Significance of Nucleolus in Colon Cancer Tissue

竑宇曲

Advances in Clinical Medicine 2024 14 03
Handbook of Cancer and Immunology

Elizabeth Gonzalez Dominguez, Terrie Flatt, Atif Ali Ahmed

2023

PreviousNext

In this issue

Saudi Medical Journal

Vol. 37, Issue 12

1 Dec 2016

Table of Contents
Cover (PDF)
Index by author

Download PDF

Email Article

Thank you for your interest in spreading the word on Saudi Medical Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Roles of nucleolin

Message Subject (Your Name) has sent you a message from Saudi Medical Journal

Message Body (Your Name) thought you would like to see the Saudi Medical Journal web site.

Your Personal Message

Citation Tools

Roles of nucleolin

Zhuo Chen, XinHua Xu

Saudi Medical Journal Dec 2016, 37 (12) 1312-1318; DOI: 10.15537/smj.2016.12.15972

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Roles of nucleolin

Zhuo Chen, XinHua Xu

Saudi Medical Journal Dec 2016, 37 (12) 1312-1318; DOI: 10.15537/smj.2016.12.15972

Share This Article:

Tweet Widget
Facebook Like
Google Plus One

Bookmark this article

User Name *

Password *

Remember my user name & password.

Jump to section

Article
- Abstract
- References
Figures & Data
eLetters
References
Info & Metrics
PDF

No related articles found.

PubMed
Google Scholar

Cited By...

No citing articles found.

Google Scholar

Main menu

User menu

Search

Roles of nucleolin

Focus on cancer and anti-cancer therapy

Article Information

Author Information

Cited By...

In this issue

Citation Manager Formats

Related Articles

Cited By...

More in this TOC Section

Similar Articles

CONTENT

JOURNAL

AUTHORS